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Inventi Impact: Med Chem

Articles

  • Inventi:pmc/33739/21
    Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza a Virus Activity
    Research 2021 : April - June
    Claudio Zippilli, Lorenzo Botta, Bruno Mattia Bizzarri, Lucia Nencioni, Marta De Angelis, Virginia Protto, Gianluca Giorgi, Maria Camilla Baratto, Rebecca Pogni, Raffaele Saladino

    Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle.

    How to Cite this Article
    Attribution/ CC Compliant Citation: Zippilli, Claudio, et al. "Laccase-Catalyzed 1, 4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity." International journal of molecular sciences 22.3 (2021): 1337. https://doi.org/10.3390/ijms22031337 http://creativecommons.org/licenses/by/4.0/ Some formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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